Remdesivir
Cat. No.：YN250103
| 产品名称: | Remdesivir |
| CAS No.: | 1809249-37-3 |
| Chemical Name: | N-[(S)-hydroxyphenoxyphosphinyl)-L-alanine, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile |
| Synonyms: | 瑞德西韦; GS-5734 |
| 分子量: | 602.58 |
| 分子式: | C₂₇H₃₅N₆O₈P |
| SMILES: | C[C@H](N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O)C(OCC(CC)CC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Remdesivir (GS-5734) 是一种核苷类似物，具有抗病毒活性，在 HAE 细胞中，对SARS-CoV和MERS-CoV的EC50值为 74 nM，在延迟脑肿瘤细胞中，对鼠肝炎病毒的EC50值为 30 nM。Remdesivir 有潜力用于 2019-nCoV (COVID-19) 研究。 |
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Agostini, M.L., Andres, E.L., Sims, A.C., et al.Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonucleasemBio9(2),e00221-00218(2018)
Sheahan, T.P., Sims, A.C., Graham, R.L., et al.Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronavirusesSci. Transl. Med.9(396),eaal3653(2017)
Eastman, R.T., Roth, J.S., Brimacombe, K.R., et al.Remdesivir: A review of its discovery and development leading to emergency use authorization for treatment of COVID-19ACS Cent. Sci.6(5),672-683(2020)
Pruijssers, A.J., George, A.S., Schäfer, A., et al.Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in miceCell Rep.32(3),107940(2020)
Hu, W.-J., Chang, L., Yang, Y., et al.Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in miceActa Pharmacol. Sin.12,(2020)
