Carmofur
Cat. No.：YN250934
| 产品名称: | Carmofur |
| CAS No.: | 61422-45-5 |
| Chemical Name: | 5-fluoro-N-hexyl-3,4-dihydro-2H,4-dioxo-1-pyrimidinecarboxamide |
| Synonyms: | 卡莫氟; HCFU |
| 分子量: | 257.26 |
| 分子式: | C₁₁H₁₆FN₃O₃ |
| SMILES: | O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Carmofur (HCFU) 是 5-氟尿嘧啶的衍生物，是一种抗肿瘤药物。Carmofur 是一种酸性神经酰胺酶 (acid ceramidase) 抑制剂，对大鼠的IC50为 79 nM。Carmofur 抑制 SARS-CoV-2主要蛋白酶 (Mpro)。Carmofur 抑制 Vero E6 细胞 SARS-CoV-2，EC50为 24.3 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Realini, N., Solorzano, C., Pagliuca, C., et al.Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activitySci. Rep.3,1035(2013)
