Auranofin
Cat. No.：YN251225
| 产品名称: | Auranofin |
| CAS No.: | 34031-32-8 |
| Chemical Name: | [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-gold |
| Synonyms: | 醋硫葡金; SKF-39162 |
| 分子量: | 680.50 |
| 分子式: | C₂₀H₃₆AuO₉PS |
| SMILES: | CC(O[C@@H]1[C@@H](OC(C)=O)[C@H]([SH-][Au+]P(CC)(CC)CC)O[C@H](COC(C)=O)[C@H]1OC(C)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Auranofin (SKF-39162)是硫氧还蛋白还原酶 (TrxR) 的抑制剂，IC50为0.2 μM。Auranofin 表现出抗SARS-CoV21的抗病毒活性，对猴肾 Vero E6 细胞的 CC50为 4.2 μM。 |
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Cox, A.G., Brown, K.K., Arner, E.S.J., et al.The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidationBiochem. Pharmacol.76(9),1097-1099(2008)
Madeira, J.M., Gibson, D.L., Kean, W.F., et al.The biological activity of auranofin: Implications for novel treatment of diseasesInflammopharmacology20(6),297-306(2012)
Lewis, M.G., DaFonseca, S., Chomont, N., et al.Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspensionAIDS25(11),1347-1356(2011)
Lippmann, J., Petri, K., Fulda, S., et al.Redox modulation and induction of ferroptosis as a new therapeutic strategy in hepatocellular carcinomaTransl. Oncol.13(8),100785(2020)
