Z-FA-FMK
Cat. No.：YN251801
| 产品名称: | Z-FA-FMK |
| CAS No.: | 197855-65-5 |
| Chemical Name: | N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester |
| Synonyms: | (1S) |
| 分子量: | 386.42 |
| 分子式: | C₂₁H₂₃FN₂O₄ |
| SMILES: | O=C(OCC1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(NC(C)C(CF)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) 是一种广谱的卤代甲基酮抑制剂，可抑制冠状病毒 (SARS-CoV) 蛋白酶3CL，Ki为 25.7 μM。 |
| IC50和靶点: | |
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Ahmed, N.K., Martin, L.A., Watts, L.M., et al.Peptidyl fluoromethyl ketones as inhibitors of cathepsin B. Implication for treatment of rheumatoid arthritisBiochem. Pharmacol.44(6),1201-1207(1992)
Lopez-Hernandez, F.J., Ortiz, M.A., Bayon, Y., et al.Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathwayMol. Cancer Ther.2(3),255-263(2003)
Harth, G., Andrews, N., Mills, A.A., et al.Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruziMol. Biochem. Parasitol.58(1),17-24(1993)
Lawrence, C.P., Kadioglu, A., Yang, A.L., et al.The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivoJ. Immunol.177(6),3827-3836(2006)
Kim, M., Hansen, K.K., Davis, L., et al.Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivoAntivir.Ther.15(6),897-905(2010)
