SPHINX31
Cat. No.：YN290157
CAS No. ：1818389-84-2
| 产品名称: | SPHINX31 |
| CAS No.: | 1818389-84-2 |
| Chemical Name: | 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-2-furancarboxamide |
| Synonyms: | SPHINX31 |
| 分子量: | 507.51 |
| 分子式: | C₂₇H₂₄F₃N₅O₂ |
| SMILES: | O=C(NC1=C(N2CCN(CC3=CC=CC=N3)CC2)C=CC(C(F)(F)F)=C1)C4=CC=C(O4)C5=CC=NC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SPHINX31 是有效的、丝氨酸/富含精氨酸的蛋白激酶1(SRPK1)的选择性抑制剂，其IC50值为 5.9 nM。SPHINX31 能够抑制丝氨酸/丰富精氨酸的剪接因子1 (SRSF1)的磷酸化。SPHINX31有用于局部研究新生血管性眼病的潜力。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Batson, J., Toop, H.D., Redondo, C., et al.Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye diseaseACS Chem. Biol.Epub ahead of print,(2017)
