Escitalopram
Cat. No.：YN380096
CAS No. ：128196-01-0
| 产品名称: | Escitalopram |
| CAS No.: | 128196-01-0 |
| Chemical Name: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile |
| Synonyms: | 依他普仑; (S)-Citalopram; (S)-(+)-Citalopram |
| 分子量: | 324.39 |
| 分子式: | C₂₀H₂₁FN₂O |
| SMILES: | FC1=CC=C([C@@]2(CCCN(C)C)C(C=CC(C#N)=C3)=C3CO2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Escitalopram ((S)-Citalopram) 是外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂(SSRI)，Ki为 0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。Escitalopram 对多巴胺转运体 (DAT) 和去甲肾上腺素转运体 (NET) 均有选择性。Escitalopram 是研究抑郁症的抗抑郁药。 |
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Höschl, C., and Svestka, J.Escitalopram for the treatment of major depression and anxiety disordersExpert Rev. Neurother.8(4),537-552(2008)
Zhang, P., Cyriac, G., Kopajtic, T., et al.Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transportersJ. Med. Chem.53(16),6112-6121(2010)
Sánchez, C., Bøgesø, K.P., Ebert, B., et al.Escitalopram versus citalopram: The surprising role of the R-enantiomerPsychopharmacology (Berl)174(2),163-176(2004)
Sánchez, C., Bergqvist, P.B.F., Brennum, L.T., et al.Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activitiesPsychopharmacol. (Berl)167(4),353-362(2003)
Carpinteiro, A., Edwards, M.J., Hoffmann, M., et al.Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cellsCell Rep. Med.1(8),100142(2020)
