Duloxetine hydrochloride
Cat. No.：YN380161
CAS No. ：136434-34-9
| 产品名称: | Duloxetine hydrochloride |
| CAS No.: | 136434-34-9 |
| Chemical Name: | N-methyl-γS-(1-naphthalenyloxy)-2-thiophenepropanamine, monohydrochloride |
| Synonyms: | 盐酸度洛西汀; (S) |
| 分子量: | 333.88 |
| 分子式: | C₁₈H₂₀ClNOS |
| SMILES: | CNCC[C@H](OC1=CC=CC2=C1C=CC=C2)C3=CC=CS3.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI)，Ki为 4.6 nM，可作用于广泛性焦虑症。 |
| IC50和靶点: | |
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Wong, D.T., Bymaster, F.P., Mayle, D.A., et al.LY248686, a new inhibitor of serotonin and norepinephrine uptakeNeuropsychopharmacology8(1),23-33(1993)
Kasamo, K., Blier, P., and De Montigny, C.Blockade of the serotonin and norepinephrine uptake processes by duloxetine: In vitro and in vivo studies in the rat brainJ. Pharmacol. Exp. Ther.277(1),278-286(1996)
Castagné, V., Porsolt, R.D., and Moser, P.Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouseEur. J. Pharmacol.616(1-3),128-133(2009)
