Paroxetine hydrochloride
Cat. No.：YN380177
| 产品名称: | Paroxetine hydrochloride |
| CAS No.: | 78246-49-8 |
| Chemical Name: | (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine, monohydrochloride |
| Synonyms: | 盐酸帕罗西汀; BRL29060 hydrochloride; BRL29060A |
| 分子量: | 365.83 |
| 分子式: | C₁₉H₂₁ClFNO₃ |
| SMILES: | FC1=CC=C([C@H]2[C@H](COC3=CC=C(OCO4)C4=C3)CNCC2)C=C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Paroxetine hydrochloride 是一种抗抑郁药，为高效的五羟色胺再摄取抑制剂，能抑制 GRK2 活性，IC50值为 14 μM。 |
| IC50和靶点: | |
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Mattson, R.J., Catt, J.D., Denhart, D.J., et al.Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitorsJ. Med. Chem.48(19),6023-6034(2005)
Owens, M.J., Neal, W., Plott, S.J., et al.Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolitesJ. Pharmacol. Exp. Ther.283(3),1305-1322(1997)
Sugimoto, Y., Tagawa, N., Kobayashi, Y., et al.Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetineEur. J. Pharmacol.696(1-3),96-100(2012)
