Desvenlafaxine
Cat. No.：YN380180
| 产品名称: | Desvenlafaxine |
| CAS No.: | 93413-62-8 |
| Chemical Name: | 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol |
| Synonyms: | 去甲文拉法辛; O-Desmethylvenlafaxine |
| 分子量: | 263.38 |
| 分子式: | C₁₆H₂₅NO₂ |
| SMILES: | OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Desvenlafaxine 是 Venlafaxine (HY-B0196) 主要代谢物的丁二酸盐形式，是具有口服活性的、能透过血脑屏障的5-HT和 去甲肾上腺素 (norepinephrine) 再摄取的抑制剂，对 hSERT和 hNET 的IC50值分别为 47.3 nM和 531.3 nM。Desvenlafaxine 在人多巴胺(DA)转运体上显示弱的结合亲和力。 |
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Deecher, D.C., Beyer, C.E., Johnston, G., et al.Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitorJ. Pharmacol. Exp. Ther.318(2),657-665(2006)
Otton, S.V., Ball, S.E., Cheung, S.W., et al.Venlafaxine oxidation in vitro is catalysed by CYP2D6Br. J. Clin. Pharmacol.41(2),149-156(1996)
Malick, M., Gilbert, K., Brouillette, J., et al.Cognitive deficits following a post-myocardial infarct in the rat are blocked by the serotonin-norepinephrine reuptake inhibitor desvenlafaxineInt. J. Mol. Sci.19(12),E3748(2018)
