Desvenlafaxine succinate hydrate
Cat. No.：YN380181
CAS No. ：386750-22-7
| 产品名称: | Desvenlafaxine succinate hydrate |
| CAS No.: | 386750-22-7 |
| Chemical Name: | butanedioic acid, compd. with 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, hydrate (1:1:1) |
| Synonyms: | 琥珀酸去甲文拉法辛; O-Desmethylvenlafaxine succinate hydrate |
| 分子量: | 399.48 |
| 分子式: | C₂₀H₃₃NO₇ |
| SMILES: | OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1.O=C(O)CCC(O)=O.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Desvenlafaxine succinate hydrate 是 Venlafaxine (HY-B0196) 主要代谢物的丁二酸盐形式，是具有口服活性的、能透过血脑屏障的5-HT和 去甲肾上腺素 (norepinephrine) 再摄取的抑制剂，对 hSERT 和 hNET 的IC50值分别为47.3 nM和531.3 nM。 Desvenlafaxine succinate hydrate 在人多巴胺 (DA) 转运体上显示弱的结合亲和力。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Deecher, D.C., Beyer, C.E., Johnston, G., et al.Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitorJ. Pharmacol. Exp. Ther.318(2),657-665(2006)
Otton, S.V., Ball, S.E., Cheung, S.W., et al.Venlafaxine oxidation in vitro is catalysed by CYP2D6Br. J. Clin. Pharmacol.41(2),149-156(1996)
Malick, M., Gilbert, K., Brouillette, J., et al.Cognitive deficits following a post-myocardial infarct in the rat are blocked by the serotonin-norepinephrine reuptake inhibitor desvenlafaxineInt. J. Mol. Sci.19(12),E3748(2018)
