AGK2
Cat. No.：YN310017
CAS No. ：304896-28-4
| 产品名称: | AGK2 |
| CAS No.: | 304896-28-4 |
| Chemical Name: | 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide |
| Synonyms: | 2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺 |
| 分子量: | 434.27 |
| 分子式: | C₂₃H₁₃Cl₂N₃O₂ |
| SMILES: | O=C(NC1=C2C=CC=NC2=CC=C1)/C(C#N)=C/C3=CC=C(C4=CC(Cl)=CC=C4Cl)O3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AGK2 是一个选择性SIRT2抑制剂，其IC50值为 3.5 μM。AGK2 抑制 SIRT1 和 SIRT3，IC50值分别为 30 和 91 μM。 |
| IC50和靶点: | [{name:"SIRT2:3.5 μM (IC50)"},{name: "SIRT1:30 μM (IC50)"},{name: "SIRT3:91 μM (IC50)"}] |
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| Solvent & Solubility: |
Outeiro, T.F., Kontopoulos, E., Altmann, S.M., et al.Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's diseaseScience317(5837),516-519(2007)
