Cambinol
Cat. No.：YN310025
CAS No. ：14513-15-6
| 产品名称: | Cambinol |
| CAS No.: | 14513-15-6 |
| Chemical Name: | 2,3-dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone |
| Synonyms: | SIRT1/2 Inhibitor IV,NSC 112546 |
| 分子量: | 360.43 |
| 分子式: | C₂₁H₁₆N₂O₂S |
| SMILES: | O=C(C(CC1=C2C=CC=CC2=CC=C1O)=C(C3=CC=CC=C3)N4)NC4=S |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cambinol 是一种SIRT1和SIRT2的抑制剂，IC50值分别为 56 μM 和 59 μM。Cambinol 是中性鞘磷脂酶(N-SMase)的抑制剂(外泌体抑制剂)。 |
| IC50和靶点: | [{name:"SIRT1:56 μM (IC50)"},{name: "SIRT2:59 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Heltweg, B., Gatbonton, T., Schuler, A.D., et al.Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymesCancer Res.66(8),4368-4377(2006)
Laemmle, A., Lechleiter, A., Roh, V., et al.Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditionsPLoS One7(3),(2012)
