CAY10602
Cat. No.：YN310072
CAS No. ：374922-43-7
| 产品名称: | CAY10602 |
| CAS No.: | 374922-43-7 |
| Chemical Name: | 1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine |
| Synonyms: | 3-(benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine;AC1LZ7PQ;SureCN3483653;Oprea1_667095;STOCK2S-06230;MolPort-002-559-207;CAY10602;STL303186;1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine;CAY 10602;C22H15FN4O |
| 分子量: | 418.44 |
| 分子式: | C₂₂H₁₅FN₄O₂S |
| SMILES: | NC1=C(S(=O)(C2=CC=CC=C2)=O)C3=NC4=CC=CC=C4N=C3N1C5=CC=C(F)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CAY10602 是一种SIRT1的激活剂。CAY10602 剂量依赖性地抑制 THP-1 细胞中脂多糖对 NF-κB 的 TNF-α 依赖性诱导。 |
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Nayagam, V.M., Wang, X., Tan, Y.C., et al.SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agentsJ. Biomol. Screen.11(8),959-967(2006)
Sui, S., Zhang, J., Xu, S., et al.Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cellsCell Death Dis.10,331(2019)
Jiang, Y., Chen, D., Gong, Q., et al.Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver diseaseLipids Health Dis.20(1),40(2021)
