OSS_128167
Cat. No.：YN310082
CAS No. ：887686-02-4
| 产品名称: | OSS_128167 |
| CAS No.: | 887686-02-4 |
| Chemical Name: | 5-[[3-[(2-furanylcarbonyl)amino]benzoyl]amino]-2-hydroxy-benzoic acid |
| Synonyms: | SIRT6-IN-1 |
| 分子量: | 366.32 |
| 分子式: | C₁₉H₁₄N₂O₆ |
| SMILES: | O=C(C1=CC(NC(C2=CC=CO2)=O)=CC=C1)NC3=CC(C(O)=O)=C(O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | OSS_128167 是一种有效的选择性沉默调节蛋白 6 (SIRT6) 抑制剂，对SIRT6，SIRT1 和 SIRT2 的IC50分别为 89 μM，1578 μM 和 751 μM。OSS_128167 具有抗HBV活性，可抑制HBV的转录和复制。OSS_128167 具有抗癌，抗炎和抗病毒作用。 |
| IC50和靶点: | [{name:"SIRT6:89 μM (IC50)"},{name: "SIRT2:751 μM (IC50)"},{name: "SIRT1:1578 μM (IC50)'}, 'HBV'] |
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Damonte, P., Sociali, G., Parenti, M.D., et al.SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effectsBioorg. Med. Chem.25(20),5849-5858(2017)
Zuo, Y., Huang, L., Enkhjargal, B., et al.Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in ratsJ. Neuroinflammation16(1):47,(2019)
