Sirtinol
Cat. No.：YN310221
CAS No. ：410536-97-9
| 产品名称: | Sirtinol |
| CAS No.: | 410536-97-9 |
| Chemical Name: | 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-benzamide |
| Synonyms: | 2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺 |
| 分子量: | 394.47 |
| 分子式: | C₂₆H₂₂N₂O₂ |
| SMILES: | O=C(NC(C1=CC=CC=C1)C)C2=CC=CC=C2/N=C/C3=C4C=CC=CC4=CC=C3O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sirtinol 是sirtuin (SIRT)的抑制剂，对 ySir2，hSIRT2 和 hSIRT2 的IC50值分别为 48 μM，57.7 μM 和 131 μM。 |
| IC50和靶点: | [{name:"ySir2:48 μM (IC50)"},{name: "hSIRT2:57.7 μM (IC50)"},{name: "hSIRT1:131 μM (IC50)"}] |
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| Solvent & Solubility: |
Grozinger, C.M., Chao, E.D., Blackwell, H.E., et al.Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screeningJ. Biol. Chem.276(42),38837-38843(2001)
Ota, H., Tokunaga, E., Chang, K., et al.Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cellsOncogene25(2),176-185(2006)
Cea, M., Soncini, D., Fruscione, F., et al.Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cellsPLoS One6(7),1-12(2011)
Orecchia, A., Scarponi, C., Di Felice, F., et al.Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cellsPLoS One6(9),1-12(2011)
Zhao, Y., Dai, X., Blackwell, H.E., et al.SIR1, an upstream component in auxin signaling identified by chemical geneticsScience301(5636),1107-1110(2003)
Dai, X., Hayashi, K.i., Nozaki, H., et al.Genetic and chemical analyses of the action mechanisms of sirtinol in ArabidopsisProc. Natl. Acad. Sci. USA102(8),3129-3134(2005)
