SRT 2104
Cat. No.：YN310264
CAS No. ：1093403-33-8
| 产品名称: | SRT 2104 |
| CAS No.: | 1093403-33-8 |
| Chemical Name: | 4-methyl-N-[2-[3-(4-morpholinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(3-pyridinyl)-5-thiazolecarboxamide |
| Synonyms: | GSK2245840,SRT2104,sirtuin modulator |
| 分子量: | 516.64 |
| 分子式: | C₂₆H₂₄N₆O₂S₂ |
| SMILES: | O=C(C1=C(C)N=C(C2=CC=CN=C2)S1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCOCC6)=N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SRT 2104 是一种首创、高度选择性、可通过血脑屏障的Sirt1(依赖于 NAD+) 激活剂，增加 Sirt1 蛋白水平，但对其 mRNA 无作用。用于糖尿病和亨廷顿氏症的研究。 |
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Ma, F., Wu, J., Jiang, Z., et al.P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathyBiochim. Biophys. Acta Mol. Cell Res.1866(8),1272-1281(2019)
Jiang, M., Zheng, J., Peng, Q., et al.Sirtuin 1 activator SRT2104 protects Huntington's disease miceAnn. Clin. Transl. Neurol.1(12),1047-1052(2014)
