Selisistat
Cat. No.：YN310266
CAS No. ：49843-98-3
| 产品名称: | Selisistat |
| CAS No.: | 49843-98-3 |
| Chemical Name: | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Synonyms: | EX-527 |
| 分子量: | 248.71 |
| 分子式: | C₁₃H₁₃ClN₂O |
| SMILES: | O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Selisistat (EX-527) 是一种有效，选择性的SIRT1抑制剂，IC50为 98 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Napper, A.D., Hixon, J., McDonagh, T., et al.Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1J. Med. Chem.48(25),8045-8054(2005)
Peck, B., Chen, C.-Y., Ho, K.-K., et al.SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2Mol. Cancer Ther.9(4),844-855(2010)
