Tenovin-6 Hydrochloride
Cat. No.：YN310270
| 产品名称: | Tenovin-6 Hydrochloride |
| CAS No.: | 1011301-29-3 |
| Chemical Name: | N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide, monohydrochloride |
| Synonyms: | |
| 分子量: | 491.09 |
| 分子式: | C₂₅H₃₅ClN₄O₂S |
| SMILES: | O=C(NC(NC1=CC=C(NC(CCCCN(C)C)=O)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tenovin-6 Hydrochloride 是 Tenovin-1 (HY-13423) 的类似物，是一种p53转录活性的激活剂。Tenovin-6 Hydrochloride 抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。Tenovin-6 Hydrochloride 也能抑制二氢乳清酸脱氢酶(DHODH)。 |
| IC50和靶点: | [{name:"SIRT2:10 μM (IC50)"},{name: "SIRT1:21 μM (IC50)"},{name: "SIRT3:67 μM (IC50)'}, 'HDAC8', 'MDM-2/p53'] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lain, S., Hollick, J.J., Campbell, J., et al.Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activatorCancer Cell13(5),454-463(2008)
