AK-7
Cat. No.：YN310295
CAS No. ：420831-40-9
| 产品名称: | AK-7 |
| CAS No.: | 420831-40-9 |
| Chemical Name: | N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide |
| Synonyms: | Ak 7;AK-7;3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide;C19H21BrN2O3S;308B6B695N;3-(1-azepanylsulfonyl)-N-(3-bromophenyl)benzamide;3-(azepane-1-sulfonyl)-N-(3-bromophenyl)benzamide;Oprea1_876929;MLS006011706;SIRT2 Inhibitor II, AK-7;HMS3740I05;HMS388 |
| 分子量: | 437.35 |
| 分子式: | C₁₉H₂₁BrN₂O₃S |
| SMILES: | O=S(N1CCCCCC1)(C2=CC(C(NC3=CC(Br)=CC=C3)=O)=CC=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AK-7 是一种可透过细胞及血脑屏障的SIRT2抑制剂，IC50值为 15.5 μM。 |
| IC50和靶点: | [{name:"SIRT2:15.5 μM (IC50)"}] |
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| Solvent & Solubility: |
de Oliveira, R.M., Sarkander, J., Kazantsev, A.G., et al.SIRT2 as a therapeutic target for age-related disordersFront. Pharmacol.3,82(2012)
Fridén-Saxin, M., Seifert, T., Landergren, M.R., et al.Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitorsJ. Med. Chem.55,7104-7113(2012)
Xu, K., Dai, X.L., Huang, H.C., et al.Targeting HDACs: A promising therapy for Alzheimer's diseaseOxid. Med. Cell. Longev.,143269(2011)
Taylor, D.M., Balabadra, U., Xiang, Z., et al.A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylaseACS Chem Biol.6(6),540-546(2011)
