Nicotinamide
Cat. No.：YN310336
| 产品名称: | Nicotinamide |
| CAS No.: | 98-92-0 |
| Chemical Name: | 3-pyridinecarboxamide |
| Synonyms: | 烟酰胺; Niacinamide; Nicotinic acid amide |
| 分子量: | 122.12 |
| 分子式: | C₆H₆N₂O |
| SMILES: | O=C(C1=CC=CN=C1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nicotinamide是一种B3维生素，通过促进NAD +氧化还原稳态和提供NAD +作为催化非氧化还原反应的一类酶的底物，在细胞生理学中发挥重要作用。 烟酰胺是SIRT1的抑制剂。 |
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Li, F., Chong, Z.Z., and Maiese, K.Cell life versus cell longevity: The mysteries surrounding the NAD+ precursor nicotinamideCurr. Med. Chem.13(8),883-895(2006)
Bitterman, K.J., Anderson, R.M., Cohen, H.Y., et al.Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1J. Biol. Chem.277(47),45099-45107(2002)
Tanno, O., Ota, Y., Kitamura, N., et al.Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrierBr. J. Dermatol.143(3),524-531(2000)
Park, S.Y., Lee, K.B., Lee, M.-J., et al.Nicotinamide inhibits the early stage of carcinogen-induced hepatocarcinogenesis in mice and suppresses human hepatocellular carcinoma cell growthJ. Cell. Physiol.227(3),899-908(2012)
Lukasova, M., Hanson, J., Tunaru, S., et al.Nicotinic acid (niacin): New lipid-independent mechanisms of action and therapeutic potentialsTrends Pharmacol. Sci.32(12),700-707(2011)
Bodor, E.T., and Offermanns, S.Nicotinic acid: An old drug with a promising futureBr. J. Pharmacol.153(Suppl 1),S68-S75(2008)
Haining, C.G.Effects of anti-rheumatic compounds and pyridine derivatives on the cutaneous response to thurfyl nicotinate in the guinea-pigBr. J. Pharmacol. Chemother.21(1),104-112(1963)
