Suramin
Cat. No.：YN310338
| 产品名称: | Suramin |
| CAS No.: | 145-63-1 |
| Chemical Name: | |
| Synonyms: | 苏拉明 |
| 分子量: | 1297.28 |
| 分子式: | C₅₁H₄₀N₆O₂₃S₆ |
| SMILES: | O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O)=O)C4=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O)=O)C8=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C78)=O)=CC=C6C)=O)=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Suramin 是一种可逆的，竞争性蛋白酪氨酸磷酸酶 (PTPases) 抑制剂。Suramin 是有效的sirtuins抑制剂：SirT1 (IC50=297 nM)，SirT2 (IC50=1.15 μM)，SirT5 (IC50=22 μM)。Suramin 是竞争性逆转录酶抑制剂 (DNA topoisomerase II:IC50=5 μM)。Suramin 有效抑制IP5K，并且是抗寄生虫 (antiparasitic)，抗肿瘤和抗血管生成剂。 |
| IC50和靶点: | [{name:"SIRT1:297 nM (IC50)"},{name: "SIRT2:1.15 μM (IC50)"},{name: "SIRT5:22 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
