Suramin sodium salt
Cat. No.：YN310339
| 产品名称: | Suramin sodium salt |
| CAS No.: | 129-46-4 |
| Chemical Name: | 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid, hexasodium salt |
| Synonyms: | 苏拉明钠; Suramin hexasodium salt |
| 分子量: | 1429.17 |
| 分子式: | C₅₁H₃₄N₆Na₆O₂₃S₆ |
| SMILES: | O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2C)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6C)=O)=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Suramin sodium salt (Suramin hexasodium salt) 是一种可逆的竞争性蛋白酪氨酸磷酸酶 (PTPases) 抑制剂。Suramin sodium salt 是有效的sirtuins抑制剂：SirT1 (IC50=297 nM)，SirT2 (IC50=1.15 μM)，SirT5 (IC50=22 μM)。Suramin sodium salt 是竞争性逆转录酶抑制剂 (DNA topoisomerase II:IC50=5 μM)。Suramin sodium s |
| IC50和靶点: | [{name:"SIRT1:297 nM (IC50)"},{name: "SIRT2:1.15 μM (IC50)"},{name: "SIRT5:22 μM (IC50)"}] |
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Wiedemar, N., Hauser, D.A., and Mäser, P.100 years of suraminAntimicrob. Agents Chemother.64(3),e01168-01119(2020)
Klinger, M., Bofill-Cardona, E., Mayer, B., et al.Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sitesBiochem. J.355(3),827-833(2001)
Charlton, S.J., Brown, C.A., Weisman, G.A., et al.PPADS and suramin as antagonists at cloned P2Y- and P2U- purinoceptorsBr. J. Pharmacol.118(3),704-710(1996)
Tan, C.W., Sam, I.-C., Chong, W.L., et al.Polysulfonate suramin inhibits Zika virus infectionAntiviral Res.143,186-194(2017)
Khanra, S., Juin, S.K., Jawed, J.J., et al.In vivo experiments demonstrate the potent antileishmanial efficacy of repurposed suramin in visceral leishmaniasisPLoS Negl. Trop. Dis.14(8),e0008575(2020)
Salvador, G.H.M., Dreyer, T.R., Gomes, A.A.S., et al.Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanismSci. Rep.8(1),10317(2018)
Chahinian, A.P., Mandeli, J.P., Gluck, H., et al.Effectiveness of cisplatin, paclitaxel, and suramin against human malignant mesothelioma xenografts in athymic nude miceJ. Surg. Oncol.67(2),104-111(1998)
