Ganoderic acid D
Cat. No.：YN310351
| 产品名称: | Ganoderic acid D |
| CAS No.: | 108340-60-9 |
| Chemical Name: | 7β-hydroxy-3,11,15,23-tetraoxo-lanost-8-en-26-oic acid |
| Synonyms: | 灵芝酸 D |
| 分子量: | 514.65 |
| 分子式: | C₃₀H₄₂O₇ |
| SMILES: | CC1(C)C(CC[C@]2(C)C3=C([C@@]4(C(C[C@@H]([C@]4(CC3=O)C)[C@H](C)CC(CC(C)C(O)=O)=O)=O)C)[C@@H](O)C[C@@]12[H])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ganoderic acid D 是一种高度氧化的四环三萜类化合物 (tetracyclic triterpenoid)，是灵芝 (Ganoderma lucidum) 的主要活性成分。Ganoderic acid D 上调SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D (CypD)。Ganoderic acid D 抑制结肠癌细胞的能量重编程，包括结肠癌细胞中的葡萄糖摄取，乳酸产生，丙酮酸和乙酰辅酶的产生。Ganoderic acid D 诱导 HeLa 人宫颈癌细胞凋亡 (apo |
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Liu, Z., Li, L., and Xue, B.Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin DEur. J. Pharmacol.824,72-77(2018)
Ruan, W., Lim, A.H.H., Huang, L.G., et al.Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growthNat. Prod. Res.28(24),2264-2272(2014)
