Dihydrocoumarin
Cat. No.：YN310352
| 产品名称: | Dihydrocoumarin |
| CAS No.: | 119-84-6 |
| Chemical Name: | 3,4-dihydro-2H-1-benzopyran-2-one |
| Synonyms: | 二氢香豆素; Hydrocoumarin; Chroman-2-one |
| 分子量: | 148.16 |
| 分子式: | C₉H₈O₂ |
| SMILES: | O=C1CCC2=CC=CC=C2O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dihydrocoumarin 是在Melilotus officinalis中发现的一种化合物。Dihydrocoumarin 是酵母Sir2p抑制剂。 Dihydrocoumarin 还抑制人SIRT1和SIRT2，IC50分别为 208 μM 和 295 μM。 |
| IC50和靶点: | [{name:"hSIRT1:208 μM (IC50)"},{name: "hSIRT2:295 μM (IC50)"}] |
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Olaharski, A.J., Rine, J., Marshall, B.L., et al.The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylasesPLoS Genet.1(6),e77(2005)
Lake, B.G., Evans, J.G., Lewis, D.F., et al.Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the ratFood Chem. Toxicol.32(8),743-751(1994)
