SAG
Cat. No.：YN450067
CAS No. ：912545-86-9
规格
价格(RMB)
库存
| 产品名称: | SAG |
| CAS No.: | 912545-86-9 |
| Chemical Name: | 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide |
| Synonyms: | Smoothened Agonist (SAG) HCl,Smoothened Agonist |
| 分子量: | 490.06 |
| 分子式: | C₂₈H₂₈ClN₃OS |
| SMILES: | O=C(C1=C(Cl)C2=CC=CC=C2S1)N([C@H]3CC[C@H](NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SAG 是一种有效的Smoothened (Smo)受体激动剂 (EC50=3 nM;Kd=59 nM)。SAG 可激活 Hedgehog 信号通路并抵消 Cyclopamine (HY-17024) 对 Smo 的抑制作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Chen, J.K., Taipale, J., Young, K.E., et al.Small molecule modulation of smoothened activityProc. Natl. Acad. Sci. USA99(22),14071-14076(2002)
Frank-Kamenetsky, M., Zhang, X.M., Bottega, S., et al.Small-molecule modulators of Hedgehog signaling: Identification and characterization of smoothened agonists and antagonistsJ. Biol.1(2),10(2002)
Yang, H., Xiang, J., Wang, N., et al.Converse conformational control of smoothened activity by structurally related small moleculesJ. Biol. Chem.284(31),20876-20884(2009)
Rohatgi, R., Milenkovic, L., Corcoran, R.B., et al.Hedgehog signal transduction by smoothened: Pharmacologic evidence for a 2-step activation processProc. Natl. Acad. Sci. USA106(9),3196-3201(2009)
Heine, V.M., Griveau, A., Chapin, C., et al.A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injurySci. Transl. Med.3(105),1-9(2011)
Mak, S.K., Huang, Y.A., Iranmanesh, S., et al.Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineageStem Cells Int.2012,(2012)
