BMS-833923
Cat. No.：YN450083
CAS No. ：1059734-66-5
规格
价格(RMB)
库存
| 产品名称: | BMS-833923 |
| CAS No.: | 1059734-66-5 |
| Chemical Name: | N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-benzamide |
| Synonyms: | XL-139 |
| 分子量: | 473.57 |
| 分子式: | C₃₀H₂₇N₅O |
| SMILES: | O=C(NC1=CC(CNC)=CC=C1C)C2=CC=C(NC3=NC(C4=CC=CC=C4)=C5C=CC=CC5=N3)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-833923 (XL-139)是口服生物相容性的Smoothened抑制剂，有抗肿瘤活性，能剂量依赖性抑制BODIPY cyclopamine与SMO的结合，IC50为21 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ruiz-Gómez, A., Molnar, C., Holguín, H., et al.The cell biology of Smo signalling and its relationships with GPCRsBiochim. Biophys. Acta1768(4),901-912(2007)
Sandhiya, S., Melvin, G., Kumar, S.S., et al.The dawn of hedgehog inhibitors: VismodegibJ. Pharmacol. Pharmacother.4(1),4-7(2013)
Lin, T.L., and Matsui, W.Hedgehog pathway as a drug target: Smoothened inhibitors in developmentOnco Targets Ther.5,47-58(2012)
