RK-24466
Cat. No.：YN440111
CAS No. ：213743-31-8
规格
价格(RMB)
库存
| 产品名称: | RK-24466 |
| CAS No.: | 213743-31-8 |
| Chemical Name: | 7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Synonyms: | KIN 001-51 |
| 分子量: | 370.45 |
| 分子式: | C₂₃H₂₂N₄O |
| SMILES: | NC1=C2C(N(C3CCCC3)C=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RK-24466 (KIN 001-51) 是一种高效选择性的Lck抑制剂; 抑制Lck (64-509) 和LckCD亚型的IC50值分别为小于1 和2 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Khatik, R., and Pathak, A.K.Lck inhibitors and its analogues: A reviewDer Pharma Chemica3(2),310-320(2011)
Burchat, A.F., Calderwood, D.J., Hirst, G.C., et al.Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck IIBioorg. Med. Chem. Lett.10(19),2171-2174(2000)
Arnold, L.D., Calderwood, D.J., Dixon, R.W., et al.Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck IBioorg. Med. Chem. Lett.10(19),2167-2170(2000)
Calderwood, D.J., Johnston, D.N., Munschauer, R., et al.Pyrrolo[2,3-d]pyrimidines containing diverse N-7 substituents as potent inhibitors of LckBioorg. Med. Chem. Lett.12(12),1683-1686(2002)
