AZM475271
Cat. No.：YN440279
CAS No. ：476159-98-5
规格
价格(RMB)
库存
| 产品名称: | AZM475271 |
| CAS No.: | 476159-98-5 |
| Chemical Name: | N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine |
| Synonyms: | M475271 |
| 分子量: | 442.94 |
| 分子式: | C₂₃H₂₇ClN₄O₃ |
| SMILES: | CN1CCC(COC2=CC3=NC=NC(NC4=CC(OC)=CC=C4Cl)=C3C=C2OC)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZM475271是Src激酶高效选择性抑制剂，IC50值为5nM，对Flt3、KDR和Tie-2抑制剂弱(IC50>10uM)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Plé, P.A., Green, T.P., Hennequin, L.F., et al.Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-SrcJ. Med. Chem.47(4),871-887(2004)
Yezhelyev, M.V., Koehl, G., Guba, M., et al.Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude miceClin. Cancer Res.10(23),8028-8036(2004)
