PP1
Cat. No.：YN440291
CAS No. ：172889-26-8
规格
价格(RMB)
库存
| 产品名称: | PP1 |
| CAS No.: | 172889-26-8 |
| Chemical Name: | 1-(1,1-dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Synonyms: | AGL 1872; EI 275 |
| 分子量: | 281.36 |
| 分子式: | C₁₆H₁₉N₅ |
| SMILES: | NC1=C2C(N(C(C)(C)C)N=C2C3=CC=C(C)C=C3)=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PP1 是一种有效的选择性Src家族抑制剂，抑制Lck和Fyn，IC50分别为 5 和 6 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Hanke, J.H., Gardner, J.P., Dow, R.L., et al.Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activationJ. Biol. Chem.271(2),695-701(1996)
Krystal, G.W., DeBerry, C.S., Linnekin, D., et al.Lck associates with and is activated by kit in a small cell lung cancer cell line: Inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1Cancer Res.58(20),4660-4666(1998)
Tatton, L., Morley, G.M., Chopra, R., et al.The Src-selective kinase inhibitor PP1 also inhibits kit and Bcr-Abl tyrosine kinasesJ. Biol. Chem.278(7),4847-4853(2003)
Ungefroren, H., Sebens, S., Groth, S., et al.The Src family kinase inhibitors PP2 and PP1 block TGFβ-mediated cellular responses by direct and differential inhibition of type I and type II TGFβreceptorsCurr. Cancer Drug Targets11(4),524-535(2011)
