A 419259 trihydrochloride
Cat. No.：YN440343
CAS No. ：1435934-25-0
规格
价格(RMB)
库存
| 产品名称: | A 419259 trihydrochloride |
| CAS No.: | 1435934-25-0 |
| Chemical Name: | 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, trihydrochloride |
| Synonyms: | RK 20449 trihydrochloride |
| 分子量: | 592.00 |
| 分子式: | C₂₉H₃₇Cl₃N₆O |
| SMILES: | NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1.[H]Cl.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A 419259 trihydrochloride是Src家族激酶抑制剂，对Src，Lck和Lyn的IC50分别为9 nM，3 nM，3 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Wilson, M.B., Schreiner, S.J., Choi, H.J., et al.Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesisOncogene21(53),8075-8088(2002)
Pene-Dumitrescu, T., Peterson, L.F., Donato, N.J., et al.An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259Oncogene27(56),7055-7069(2008)
Meyn, M.A., III, Schreiner, S.J., Dumitresco, T.P., et al.SRC family kinase activity is required for murine embryonic stem cell growth and differentiationMol. Pharmacol.68(5),1320-1330(2005)
Saito, Y., Yuki, H., Kuratani, M., et al.A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivoSci. Transl. Med.5(181):181ra52,(2013)
