MNS
Cat. No.：YN440414
CAS No. ：1485-00-3
规格
价格(RMB)
库存
| 产品名称: | MNS |
| CAS No.: | 1485-00-3 |
| Chemical Name: | 5-(2-nitroethenyl)-1,3-benzodioxole |
| Synonyms: | NSC 170724; 5-(2-Nitrovinyl)benzodioxole |
| 分子量: | 193.16 |
| 分子式: | C₉H₇NO₄ |
| SMILES: | O=[N+]([O-])/C=C/C1=CC(OCO2)=C2C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MNS (NSC 170724) 是 β-硝基苯乙烯衍生物，是一种有效的酪氨酸激酶抑制剂和广谱抗血小板药物。MNS 完全抑制 U46619、ADP、花生四烯酸、胶原和凝血酶诱导的血小板聚集，IC50值分别为 2.1、4.1、5.8、7.0 和 12.7 μM。MNS 抑制 Src、Syk 和 FAK，IC50分别为 27.3、2.8 和 97.6 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wang, W.Y., Wu, Y.C., and Wu, C.C.Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitorMol. Pharmacol.70(4),1380-1389(2006)
Hsieh, P.W., Chang, Y.T., Chuang, W.Y., et al.The synthesis and biologic evaluation of anti-platelet and cytotoxic β-nitrostyrenesBioorg. Med. Chem.18(21),7621-7627(2010)
Wang, W.Y., Hsieh, P.W., Wu, Y.C., et al.Synthesis and pharmacological evaluation of novel β-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activityBiochem. Pharmacol.74(4),601-611(2007)
