Sepantronium bromide
Cat. No.：YN270040
CAS No. ：781661-94-7
| 产品名称: | Sepantronium bromide |
| CAS No.: | 781661-94-7 |
| Chemical Name: | 4,9-dihydro-1-(2-methoxyethyl)2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium, bromide |
| Synonyms: | YM-155 |
| 分子量: | 443.29 |
| 分子式: | C₂₀H₁₉BrN₄O₃ |
| SMILES: | O=C1C2=C(C(C3=CC=CC=C31)=O)[N+](CC4=NC=CN=C4)=C(C)N2CCOC.[Br-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sepantronium bromide (YM-155) 是一种survivin抑制剂，其IC50为 0.54 nM。 |
| IC50和靶点: | |
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Nakamura, N., Yamauchi, T., Hiramoto, M., et al.Interleukin enhancer-binding factor 3/NF110 is a target of YM155, a suppressant of survivinMol. Cell. Proteomics11(7),(2012)
Nakahara, T., Takeuchi, M., Kinoyama, I., et al.YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenograftsCancer Res.67(17),8014-8021(2007)
Na, Y.S., Yang, S.J., Kim, S.M., et al.YM155 induces EGFR suppression in pancreatic cancer cellsPLoS One7(6),(2012)
