GSA-10
Cat. No.：YN450176
| 产品名称: | GSA-10 |
| CAS No.: | 300833-95-8 |
| Chemical Name: | 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid, propyl ester |
| Synonyms: | GSA10 |
| 分子量: | 450.5 |
| 分子式: | C26H30N2O5 |
| SMILES: | O=C(OCCC)C1=CC=C(NC(C2=C(O)C3=C(C=CC=C3)N(CCCCCC)C2=O)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSA-10 是一种有效的平滑 (Smo) 受体激动剂，其EC50值为 1.2 μM。GSA-10 是一种新型喹啉甲酰胺衍生物。GSA-10 作用于Smo，促进多能间充质干细胞分化为成骨细胞。GSA-10 介导Hedgehog(Hh) 信号传导，这可能对癌症疾病的再生医学具有研究意义。 |
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Ruiz-Gómez, A., Molnar, C., Holguín, H., et al.The cell biology of Smo signalling and its relationships with GPCRsBiochim. Biophys. Acta1768(4),901-912(2007)
Gorojankina, T., Hoch, L., Faure, H., et al.Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of SmoothenedMol. Pharmacol.83(5),1020-1029(2013)
