R406 free base
Cat. No.：YN440142
CAS No. ：841290-80-0
规格
价格(RMB)
库存
| 产品名称: | R406 free base |
| CAS No.: | 841290-80-0 |
| Chemical Name: | 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one |
| Synonyms: | R406 (free base) |
| 分子量: | 470.45 |
| 分子式: | C₂₂H₂₃FN₆O₅ |
| SMILES: | COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | R406 free base 是Syk抑制剂，IC50为41 nM，对Lyn活性较弱。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Matsubara, S., Li, G., Takeda, K., et al.Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsivenessAm. J. Respir. Crit. Care Med.173(1),56-63(2006)
Matsubara, S., Koya, T., Takeda, K., et al.Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammationAm. J. Respir. Cell Mol. Biol.34(4),426-433(2006)
Braselmann, S., Taylor, V., Zhao, H., et al.R406, an orally available spleen tyrosine kinase inhibitor blocks Fc receptor signaling and reduces immune complex-mediated inflammationJ. Pharmacol. Exp. Ther.319(3),998-1008(2006)
Buchner, M., Fuchs, S., Prinz, G., et al.Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemiaCancer Res.69(13),5424-5432(2009)
Zhang, J., Benavente, C.A., McEvoy, J., et al.A novel retinoblastoma therapy from genomic and epigenetic analysesNature481(7381),329-334(2012)
Cha, H.S., Boyle, D.L., Inoue, T., et al.A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytesJ. Pharmacol. Exp. Ther.317(2),571-578(2006)
Singh, R., Masuda, E.S., and Payan, D.G.Discovery and development of spleen tyrosine kinase (SYK) inhibitorsJ. Med. Chem.55(8),3614-3643(2012)
