BAY 61-3606 dihydrochloride
Cat. No.：YN440306
CAS No. ：648903-57-5
规格
价格(RMB)
库存
| 产品名称: | BAY 61-3606 dihydrochloride |
| CAS No.: | 648903-57-5 |
| Chemical Name: | |
| Synonyms: | BAY 61-3606,BAY-61-3606 dihydrochloride |
| 分子量: | 463.32 |
| 分子式: | C₂₀H₂₀Cl₂N₆O₃ |
| SMILES: | O=C(N)C1=CC=CN=C1NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC4=NC=CN24.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY 61-3606 dihydrochloride 是一种口服有效的，ATP 竞争性的，可逆的选择性Syk抑制剂，Ki为 7.5 nM，IC50为 10 nM。BAY 61-3606 dihydrochloride 降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化。BAY 61-3606 dihydrochloride 降低 K-rn 细胞裂解物中 Syk 磷酸化。Bay 61-3606 dihydrochloride 作用于乳腺癌细胞，通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
