Entospletinib
Cat. No.：YN440354
CAS No. ：1229208-44-9
规格
价格(RMB)
库存
| 产品名称: | Entospletinib |
| CAS No.: | 1229208-44-9 |
| Chemical Name: | 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]-imidazo[1,2-a]pyrazin-8-amine |
| Synonyms: | GS-9973 |
| 分子量: | 411.46 |
| 分子式: | C₂₃H₂₁N₇O |
| SMILES: | C12=NC=CN1C=C(C3=CC4=C(C=C3)C=NN4)N=C2NC5=CC=C(N6CCOCC6)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Entospletinib (GS-9973) 是一种可口服，选择性的Syk抑制剂，IC50值为 7.7 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Singh, R., Masuda, E.S., and Payan, D.G.Discovery and development of spleen tyrosine kinase (SYK) inhibitorsJ. Med. Chem.55(8),3614-3643(2012)
Currie, K.S., Kropf, J.E., Lee, T., et al.Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinaseJ. Med. Chem.57(9),3856-3873(2014)
Burke, R.T., Meadows, S., Loriaux, M.M., et al.A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitorOncotarget5(4),908-915(2014)
