RO9021
Cat. No.：YN440366
CAS No. ：1446790-62-0
规格
价格(RMB)
库存
| 产品名称: | RO9021 |
| CAS No.: | 1446790-62-0 |
| Chemical Name: | 6-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[(5,6-dimethyl-2-pyridinyl)amino]-3-pyridazinecarboxamide |
| Synonyms: | RO-0921,RO 0921 |
| 分子量: | 355.44 |
| 分子式: | C₁₈H₂₅N₇O |
| SMILES: | NC(C1=C(NC2=CC=C(C)C(C)=N2)C=C(N[C@H]3[C@@H](N)CCCC3)N=N1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RO9021 是一种可口服的，ATP 竞争性的SYK抑制剂，IC50值为 5.6 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Liao, C., Hsu, J., Kim, Y., et al.Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: Implications for SYK inhibitors in autoimmune disease therapyArthirits Res. Ther.15(5),R146(2013)
Arica-Sosa, A., Alcántara, R., Jiménez-Avalos, G., et al.Identifying RO9021 as a potential inhibitor of PknG from Mycobacterium tuberculosis: Combinative computational and in vitro studiesACS Omega7(23),20204-20218(2022)
Brattås, M.K., Henmsing, A.L., Rye, K.P., et al.Heterogeneity of patient-derived acute myeloid leukemia cells subjected to SYK in vitro inhibitionInt. J. Mol. Sci.23(23),14706(2022)
