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3-AP

Cat. No.:YN290016

  • CAS No. :143621-35-6

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    • 参考文献
    • 产品名称: 3-AP
      CAS No.: 143621-35-6
      Chemical Name: 2-[(3-amino-2-pyridinyl)methylene]-hydrazinecarbothioamide
      Synonyms:PAN-811; NSC# 663249; OCX191
      分子量:195.24
      分子式:C₇H₉N₅S
      SMILES:S=C(N)N/N=C/C1=NC=CC=C1N
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: 3-AP (PAN-811) 是一种核糖核苷酸还原酶 (ribonucleotide reductase,RR) 的 M2 亚基抑制剂,是有效的放射致敏剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Szekeres, T., Fritizer, M., Strobl, H., et al.Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cellsBlood84(12),4316-4321(1994)

      Barker, C.A., Burgan, W.E., Carter, D.J., et al.In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone)Clin. Cancer Res.12(9),2912-2918(2006)

      Chapman, T.R., and Kinsella, T.J.Ribonucleotide reductase inhibitors: A new look at an old target for radiosensitizationFront. Oncol.1,56(2012)

      Trondl, R., Flocke, L.S., Kowol, C.R., et al.Triapine and a more potent dimethyl derivative induce ER stress in cancer cellsMol. Pharmacol.85(3),451-459(2013)

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