Acelarin
Cat. No.：YN290020
CAS No. ：840506-29-8
| 产品名称: | Acelarin |
| CAS No.: | 840506-29-8 |
| Chemical Name: | N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-L-alanine, phenylmethyl ester |
| Synonyms: | NUC-1031 |
| 分子量: | 580.47 |
| 分子式: | C₂₅H₂₇F₂N₄O₈P |
| SMILES: | O=C1N=C(N)C=CN1[C@@H]2O[C@H](COP(OC3=CC=CC=C3)(N[C@H](C(OCC4=CC=CC=C4)=O)C)=O)[C@@H](O)C2(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Acelarin（NUC-1031）是广泛使用的核苷类似物吉西他滨的蛋白转化和增强。 |
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Thornton, P.J., Kadri, H., Miccoli, A., et al.Nucleoside phosphate and phosphonate prodrug clinical candidatesJ. Med. Chem.59(23),10400-10410(2016)
Slusarczyk, M., Lopez, M.H., Balzarini, J., et al.Application of ProTide technology to gemcitabine: A successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical developmentJ. Med. Chem.57(4),1531-1542(2014)
McGuigan, C., Habib, N.A., Wasan, H.S., et al.A phosphoramidate ProTide (NUC-1031) and acquired and intrinsic resistance to gemcitabineJ. Clin. Oncol.29(15_suppl),e13540(2016)
