IMP-1088
Cat. No.：YN290125
CAS No. ：2059148-82-0
| 产品名称: | IMP-1088 |
| CAS No.: | 2059148-82-0 |
| Chemical Name: | 5-[3,4-difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl]-N,N,1-trimethyl-1H-indazole-3-methanamine |
| Synonyms: | |
| 分子量: | 453.53 |
| 分子式: | C₂₅H₂₉F₂N₅O |
| SMILES: | CN1N=C(CN(C)C)C2=C1C=CC(C3=CC=C(F)C(F)=C3OCCC4=C(C)N(C)N=C4C)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IMP-1088 是一种有效的人 N-肉豆蔻酰基转移酶NMT1和NMT2双重抑制剂，对 HsNMT1 和 HsNMT2 的IC50为 <1 nM。IMP-1088 对 HsNMT1 的Kd为 <210 pM。IMP-1088 通过阻断鼻病毒的 N-肉豆蔻酰化蛋白 (VP0) 来有效阻断鼻病毒的复制 (rhinovirus replication)。IMP-1088 保护宿主细胞免受病毒感染的细胞毒作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mousnier, A., Bell, A.S., Swieboda, D.P., et al.Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virusNat. Chem.10(6),599-606(2018)
