ML216
Cat. No.：YN290186
CAS No. ：1430213-30-1
| 产品名称: | ML216 |
| CAS No.: | 1430213-30-1 |
| Chemical Name: | N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]-urea |
| Synonyms: | CID-49852229 |
| 分子量: | 383.32 |
| 分子式: | C₁₅H₉F₄N₅OS |
| SMILES: | O=C(NC1=CC=C(F)C(C(F)(F)F)=C1)NC2=NN=C(S2)C3=CC=NC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML216 (CID-49852229) 是一种有效，选择性，细胞渗透性的BLM解旋酶抑制剂，对BLMfull-length和BLM636-1298的IC50分别为 2.98 μM 和 0.97 μM。ML216 以Ki为 1.76 µM 来抑制BLM的 ssDNA 依赖性 ATPase 的活性。ML216 具有抗肿瘤活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Rosenthal, A.S., Dexheimer, T.S., Nguyen, G., et al.Discovery of ML216, a small molecule inhibitor of bloom (BLM) helicase,1-22(2011)
