JH-RE-06
Cat. No.：YN290208
| 产品名称: | JH-RE-06 |
| CAS No.: | 1361227-90-8 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 468.72 |
| 分子式: | C₂₀H₁₆Cl₃N₃O₄ |
| SMILES: | O=C1C(C(CC(C)C)=O)=C(NC2=CC=C(Cl)C=C2Cl)NC3=C1C([N+]([O-])=O)=CC=C3Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JH-RE-06, 有效的REV1-REV7互作抑制剂 (IC50=0.78 μM;Kd=0.42 μM)，靶向与 POLζ 的 REV7 亚基相互作用的 REV1。JH-RE-06 通过阻止诱变 POLζ 的募集来破坏诱变性跨损伤合成 (TLS)。JH-RE-06 可改善化疗效果。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
