L67
Cat. No.：YN290354
CAS No. ：325970-71-6
| 产品名称: | L67 |
| CAS No.: | 325970-71-6 |
| Chemical Name: | N-(3,5-dibromo-4-methylphenyl)-glycine, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide |
| Synonyms: | DNA Ligase Inhibitor |
| 分子量: | 486.11 |
| 分子式: | C₁₆H₁₄Br₂N₄O₄ |
| SMILES: | BrC1=CC(NCC(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)=CC(Br)=C1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L67是一种新型的竞争性 DNA连接酶抑制剂，抑制DNA连接酶I和III, IC50为10μM。 |
| IC50和靶点: | [{name:"DNA ligases I:10 μM (IC50)"},{name: "DNA ligases III:10 μM (IC50)'}, 'Caspase-1'] |
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| Solvent & Solubility: |
Chen, X., Zhong, S., Zhu, X., et al.Rational design of human DNA ligase inhibitors that target cellular DNA replication and repairCancer Res.68(9),3169-3177(2008)
Sallmyr, A., Matsumoto, Y., Roginskaya, V., et al.Inhibiting mitochondrial DNA ligase IIIα activates caspase 1-dependent apoptosis in cancer cellsCancer Res.76(18),5431-5441(2016)
