Ethynylcytidine
Cat. No.：YN290384
| 产品名称: | Ethynylcytidine |
| CAS No.: | 180300-43-0 |
| Chemical Name: | 3′-C-ethynyl-cytidine |
| Synonyms: | ECyD; TAS-106; 3'-C |
| 分子量: | 267.24 |
| 分子式: | C₁₁H₁₃N₃O₅ |
| SMILES: | OC[C@@H]1[C@@]([C@H]([C@H](N2C(N=C(C=C2)N)=O)O1)O)(C#C)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ethynylcytidine (ECyD) 是一种核苷类似物，是 RNA 合成 (RNA synthesis) 的有效抑制剂，可抑制 RNA 聚合酶 I，II 和 II。Ethynylcytidine 在多种癌症模型中均具有强大的抗肿瘤活性。 |
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Shimamoto, Y., Fujioka, A., Kazuno, H., et al.Antitumor activity and pharmacokinetics of TAS-106, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosineJpn. J. Cancer Res.92(3),343-351(2001)
Takatori, S., Kanda, H., Takenaka, K., et al.Antitumor mechanisms and metabolism of the novel antitumor nucleoside analogues, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracilCancer Chemother. Pharmacol.44(2),97-104(1999)
