TH287
Cat. No.：YN290409
CAS No. ：1609960-30-6
| 产品名称: | TH287 |
| CAS No.: | 1609960-30-6 |
| Chemical Name: | 6-(2,3-dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine |
| Synonyms: | TH287 hydrochloride |
| 分子量: | 269.13 |
| 分子式: | C₁₁H₁₀Cl₂N₄ |
| SMILES: | NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TH287 是一种有效的和选择性的MTH1抑制剂，IC50值为 0.8 nM。TH287 对 MTH1 具有高度选择性，在 100 μM 下对 MTH2，NUDT5，NUDT12，NUDT14，NUDT16，dCTPase，dUTPase 和 ITPA 没有相关抑制作用。TH287 可以作为癌症研究的化学治疗剂。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Gad, H., Koolmeister, T., Jemth, A.S., et al.MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP poolNature508,215-242(2014)
