Herboxidiene
Cat. No.：YN290469
CAS No. ：142861-00-5
| 产品名称: | Herboxidiene |
| CAS No.: | 142861-00-5 |
| Chemical Name: | 5,6-anhydro-6-C-[(2S,3E,5E)-6-[(2S,3S,6R)-6-(carboxymethyl)tetrahydro-3-methyl-2H-pyran-2-yl]-2-methyl-3,5-heptadien-1-yl]-1,4,7-trideoxy-4-methyl-3-O-methyl-L-glycero-L-gluco-heptitol |
| Synonyms: | GEX1A |
| 分子量: | 438.60 |
| 分子式: | C₂₅H₄₂O₆ |
| SMILES: | C[C@H]([C@H]([C@H](O)C)OC)[C@@]1([H])O[C@]1(C)C[C@@H](/C=C/C=C(C)/[C@H]2O[C@@H](CC(O)=O)CC[C@@H]2C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Herboxidiene (GEX1A) 是一种有效的植物毒性聚酮类化合物，来源于链霉菌 A7847，具有多种活性，包括除草、抗胆固醇、抗肿瘤等。Herboxidiene 通过与剪接体相关蛋白 (SAP) 155 结合抑制前 mRNA 剪接 (pre-mRNA splicing) 过程，SAP 是剪接体中 SF3b 的一个亚单位。 |
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Miller-Wideman, M., Makkar, N., tran, M.G.B., et al.Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physico-chemical and biological propertiesJ. Antibiot. (Tokyo)45(6),914-921(1992)
Hasegawa, M., Miura, T., Kuzuya, K., et al.Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural productACS Chem Biol.6(3),229-233(2011)
Imaizumi, T., Nakagawa, H., Hori, R., et al.The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analoguesJ Antibiot (Tokyo)70(5),675-679(2017)
Jung, H.J., Kim, Y., Shin, J.Y., et al.Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1αArch. Pharm. Res.38(9),1728-1735(2015)
Koguchi, Y., Nishio, M., Kotera, J., et al.Trichostatin A and herboxidiene up-regulate the gene expression of low density lipoprotein receptorJ. Antibiot. (Tokyo).50(11),970-971(1997)
