CRT0044876
Cat. No.：YN290555
| 产品名称: | CRT0044876 |
| CAS No.: | 6960-45-8 |
| Chemical Name: | 7-nitro-1H-indole-2-carboxylic acid |
| Synonyms: | NSC 69877,7-NO2-ICA |
| 分子量: | 206.15 |
| 分子式: | C₉H₆N₂O₄ |
| SMILES: | O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CRT0044876 是一种高效、选择性的嘌呤/嘧啶核苷核酸内切酶 1(APE1)抑制剂，IC50约为 3 μM。CRT0044876 可抑制 APE1 的 AP 内切酶、3′-磷酸二酯酶和 3′-磷酸酶活性，也是 APE1 所属的核酸外切酶 III 家族的特异性抑制剂。CRT0044876 增强了几种 DNA 碱基靶向化合物的细胞毒性。 |
| IC50和靶点: | |
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Srinivasan, A., Wang, L., Cline, C.J., et al.Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitorsBiochemistry51(31),6246-6259(2012)
Madhusudan, S., Smart, F., Shrimpton, P., et al.Isolation of a small molecule inhibitor of DNA base excision repairNucleic Acids Res.33(15),4711-4724(2005)
Mohammed, M.Z., Vyjayanti, V.N., Laughton, C.A., et al.Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell linesBr. J. Cancer104(4),653-663(2011)
Naidu, M.D., Mason, J.M., Pica, R.V., et al.Radiation resistance in glioma cells determined by DNA damage repair activity of Ape1/Ref-1J. Radiat. Res.51(4),393-404(2010)
