UNC2250
Cat. No.：YN440346
CAS No. ：1493694-70-4
规格
价格(RMB)
库存
| 产品名称: | UNC2250 |
| CAS No.: | 1493694-70-4 |
| Chemical Name: | trans-4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-cyclohexanol |
| Synonyms: | UNC 2250; UNC-2250, |
| 分子量: | 440.58 |
| 分子式: | C₂₄H₃₆N₆O₂ |
| SMILES: | CCCCNC1=NC(N[C@@H]2CC[C@@H](O)CC2)=C(C3=CC=C(CN4CCOCC4)C=N3)C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UNC2250 是一种有效选择性的Mer抑制剂，IC50为 1.7 nM，比相关的激酶 Axl 和 Tyro3 选择性高 160 倍和 60 倍。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Verma, A., Warner, S.L., Vankayalapati, H., et al.Targeting Axl and Mer kinases in cancerMol. Cancer Ther.10(10),1763-1773(2016)
Zhang, W., Zhang, D., Stashko, M.A., et al.Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitorsJ. Med. Chem.56(23),9683-9692(2013)
