LY3200882
Cat. No.：YN460001
CAS No. ：1898283-02-7
| 产品名称: | LY3200882 |
| CAS No.: | 1898283-02-7 |
| Chemical Name: | 4-[[4-[[1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy]-2-pyridinyl]amino]-α,α-dimethyl-2-pyridinemethanol |
| Synonyms: | LY3200882;19HY34R6UN;2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol;2-{4-[(4-{[1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy}pyridin-2-yl)amino]pyridin-2-yl}propan-2-o |
| 分子量: | 435.52 |
| 分子式: | C₂₄H₂₉N₅O₃ |
| SMILES: | OC(C)(C)C1=NC=CC(NC2=NC=CC(OC3=CN(C4CC4)N=C3C5CCOCC5)=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY3200882 是一种有效的，高度选择性的，具有 ATP 竞争性和口服活性的 TGF-β 受体 1 型 (ALK5) 抑制剂，IC50为 38.2 nM。LY3200882 可抑制多种促肿瘤活性，还用作免疫调节剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Pei, H., Parthasarathy, S., Joseph, S., et al.Abstract 955: LY3200882, a novel, highly selective TGFβRI small molecule inhibitorCancer Res.77(13 Supp),(2017)
