SM 16
Cat. No.：YN460004
CAS No. ：614749-78-9
| 产品名称: | SM 16 |
| CAS No.: | 614749-78-9 |
| Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-bicyclo[2.2.2]octane-1-carboxamide |
| Synonyms: | SM16; SM-16; SM 16. |
| 分子量: | 430.50 |
| 分子式: | C₂₅H₂₆N₄O₃ |
| SMILES: | O=C(C1(CC2)CCC2(C3=NC(C4=CC=C(OCO5)C5=C4)=C(C6=NC(C)=CC=C6)N3)CC1)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SM 16 是ALK5/ALK4激酶抑制剂，Ki值分别为10 和 1.5 nM。 |
| IC50和靶点: | |
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Fu, K., Corbley, M.J., Sun, L., et al.SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury modelArterioscler. Thromb. Vasc. Biol.28(4),665-671(2008)
Suzuki, E., Kim, S., Cheung, H.-K., et al.A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resectionCancer Res.67(5),2351-2359(2007)
